Pasternack A, Pettersson E, Klockars M
Nephron. 1978;22(4-6):551-7. doi: 10.1159/000181533.
In 30 patients with a variety of glomerular renal disorders, intravenously administered furosemide was associated with a significant increase of the urinary excretion of the protein fraction with a molecular weight higher than 50,000. The excretion of protein with a molecular weight less than 50,000 was not altered. In relation to endogenous clearance of creatinine the clearance of transferrin, IgG and alpha2-macroglobulin increased significantly. In relation to transferrin clearance, the clearance values of albumin and IgG remained unchanged, whereas that of alpha2-macroglobulin increased significantly. These results support the view that furosemide increases the permeability of the glomerular capillary for serum proteins.
在30例患有各种肾小球性肾脏疾病的患者中，静脉注射速尿与分子量高于50,000的蛋白质部分的尿排泄量显著增加有关。分子量小于50,000的蛋白质排泄未发生改变。与内源性肌酐清除率相关，转铁蛋白、IgG和α2-巨球蛋白的清除率显著增加。与转铁蛋白清除率相关，白蛋白和IgG的清除率值保持不变，而α2-巨球蛋白的清除率显著增加。这些结果支持速尿增加肾小球毛细血管对血清蛋白通透性的观点。
