Conn H O, Ramsby G R, Storer E H, Mutchnick M G, Joshi P H, Phillips M M, Cohen G A, Fields G N, Petroski D
Gastroenterology. 1975 Feb;68(2):211-21.
Intraarterial vasopressin has been reported to be effective in the treatment of massive upper gastrointestinal hemorrhage. A prospective, controlled clinical trial comparing conventional treatment with conventional therapy plus intraarterial vasopressin was undertaken. Sixty episodes of upper gastrointestinal hemorrhage were evaluated during a 40-month period; 32 received conventional and 28 conventional plus vasopressin therapy. The two groups of patients were similar in type and severity of their bleeding lesions and in their underlying diseases. Vasopressin was more effective in controlling hemorrhage from nonvariceal lesions (P less than 0.05) and from varices (P less than 0.01) than conventional therapy. Transfusion requirements were significantly reduced in those patients who received vasopressin. Paradoxically, survival was not affected by vasopressin administration. The failure of cessation of hemorrhage to improve survival is thought to be due to the degree of advancement of the underlying disease, to the torrential nature of the hemorrhage, to the frequency of recurrent hemorrhage, and to the use of intraarterial vasopressin in some patients in the conventional treatment group in whom conventional therapy had failed.
据报道，动脉内注射血管加压素对治疗大量上消化道出血有效。开展了一项前瞻性对照临床试验，比较传统治疗与传统治疗加动脉内注射血管加压素的效果。在40个月的时间里评估了60例上消化道出血病例；32例接受传统治疗，28例接受传统治疗加血管加压素治疗。两组患者的出血病变类型和严重程度以及基础疾病相似。血管加压素在控制非静脉曲张性病变出血（P<0.05）和静脉曲张出血（P<0.01）方面比传统治疗更有效。接受血管加压素治疗的患者输血需求显著减少。矛盾的是，血管加压素给药并未影响生存率。出血停止未能改善生存率被认为是由于基础疾病的进展程度、出血的汹涌性质、反复出血的频率以及传统治疗组中一些传统治疗失败的患者使用了动脉内血管加压素。
