Hussey K P
Arch Intern Med. 1985 Jul;145(7):1263-7.
Of four reported studies of vasopressin therapy in acute upper gastrointestinal tract hemorrhage, three found vasopressin to be effective and one did not. The studies differed with regard to population, design, and methods. The one study that found vasopressin to be ineffective in controlling gastrointestinal tract hemorrhage may have been better controlled with regard to duration of therapy and evaluation of patients. However, the population studied appeared to be different and the authors may have failed to demonstrate a beneficial effect of vasopressin in a select subgroup of patients. Vasopressin dosing has also been a point of controversy. Hemodynamic data thus far support the use of low-dose infusions. The use of terlipressin (Glypressin), a new analogue of vasopressin, also appears promising.
在四项关于血管加压素治疗急性上消化道出血的报告研究中，三项研究发现血管加压素有效，一项研究则未发现其有效。这些研究在研究对象、设计和方法方面存在差异。那项发现血管加压素在控制胃肠道出血方面无效的研究，在治疗持续时间和患者评估方面可能控制得更好。然而，所研究的对象似乎有所不同，作者可能未能在特定亚组患者中证明血管加压素的有益效果。血管加压素的给药剂量也是一个有争议的问题。迄今为止的血流动力学数据支持使用低剂量输注。血管加压素的一种新类似物特利加压素（Glypressin）的使用似乎也很有前景。
