Synthesis of a water-soluble serine-based neoglycolipid which can be covalently linked to solid phases.
作者信息
Elofsson M, Broddefalk J, Ekberg T, Kihlberg J
机构信息
Chemical Center, University of Lund, Sweden.
出版信息
Carbohydr Res. 1994 May 20;258:123-33. doi: 10.1016/0008-6215(94)84080-6.
PMID:8039173
Abstract
N alpha-Fmoc-serine pentafluorophenyl ester was glycosylated with perbenzoylated lactosyl bromide. The resulting product was coupled to a resin functionalized with 6-aminohexanoic acid and then N alpha-acylated to give a serine-based analogue of lactosylceramide. The water-soluble neoglycolipid was covalently linked to microtiter plates via its carboxyl group and was recognized by a lactose-binding lectin in an ELISA.
摘要
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