Facile synthesis of stable lipid analogues possessing a range of alkyl groups: application to artificial glycolipids.
作者信息
Azefu Yasuo, Tamiaki Hitoshi, Sato Reiko, Toma Kazunori
机构信息
Department of Bioscience and Biotechnology, Faculty of Science and Engineering, Ritsumeikan University, Kusatsu, Shiga, Japan.
出版信息
Bioorg Med Chem. 2002 Dec;10(12):4013-22. doi: 10.1016/s0968-0896(02)00266-3.
Abstract
Efficient preparation of lipid analogues is described in which various long alkoxy chains and 2-hydroxyethyl group were covalently linked with benzoic acid derivatives. An alpha-mannopyranosyl group was stereoselectively introduced by the conventional imidate method into the terminal hydroxy group without any alternation of other moieties in a molecule. The resulting new glycoconjugates acted as models of natural glycolipids for protein-carbohydrate interactions.
摘要
Zotero 插件