Azefu Yasuo, Tamiaki Hitoshi, Sato Reiko, Toma Kazunori
Department of Bioscience and Biotechnology, Faculty of Science and Engineering, Ritsumeikan University, Kusatsu, Shiga, Japan.
Bioorg Med Chem. 2002 Dec;10(12):4013-22. doi: 10.1016/s0968-0896(02)00266-3.
Efficient preparation of lipid analogues is described in which various long alkoxy chains and 2-hydroxyethyl group were covalently linked with benzoic acid derivatives. An alpha-mannopyranosyl group was stereoselectively introduced by the conventional imidate method into the terminal hydroxy group without any alternation of other moieties in a molecule. The resulting new glycoconjugates acted as models of natural glycolipids for protein-carbohydrate interactions.
