巨噬细胞介导的细胞毒性机制研究。
Studies on the mechanism of macrophage-mediated cytotoxicity.
作者信息
Ziegler F G, Lohmann-Matthes M L, Fischer H
出版信息
Int Arch Allergy Appl Immunol. 1975;48(2):182-91. doi: 10.1159/000231304.
MCF is a product of sensitized T lymphocytes, which is actively synthesized and secreted when lymphocytes are incubated with the appropriate target cells. The process of macrophage activation leading to cytotoxicity needs a period of 24h. Macrophage-mediated cytotoxicity is restricted to the specific target cell. B cell antibody does not seem to be involved. The reaction cannot be inhibited by rabbit antimouse immunoglobulin. However, various conditions, which may interfere with this specificity, are discussed.
巨噬细胞趋化因子（MCF）是致敏T淋巴细胞的产物，当淋巴细胞与合适的靶细胞一起孵育时，它会被积极合成并分泌。导致细胞毒性的巨噬细胞激活过程需要24小时。巨噬细胞介导的细胞毒性仅限于特定的靶细胞。B细胞抗体似乎未参与其中。该反应不能被兔抗小鼠免疫球蛋白抑制。然而，文中讨论了可能干扰这种特异性的各种情况。
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