Pels E, Den Otter W
Br J Cancer. 1979 Dec;40(6):856-61. doi: 10.1038/bjc.1979.276.
Many strains of mice from various breeding institutes have natural cytotoxic macrophages. These macrophages can also be present in nude mice, suggesting that this cytotoxicity can be acquired without invovlvement of T cells. The natural cytotoxicity was non-specific for tumour cells, was not sensitive to trypsin treatment, was lost after 5 days incubation, but could be enhanced by foetal bovine serum. The presence of cytotoxic macrophages in the peritoneal cavity was not genetically or age controlled. Natural cytotoxic macrophages did not occur in germ-free mice. The possible causes of natural cytotoxicity are discussed.
来自各个育种机构的许多品系小鼠都有天然细胞毒性巨噬细胞。这些巨噬细胞也可存在于裸鼠中，这表明这种细胞毒性可以在没有T细胞参与的情况下获得。这种天然细胞毒性对肿瘤细胞无特异性，对胰蛋白酶处理不敏感，培养5天后丧失，但可被胎牛血清增强。腹腔中细胞毒性巨噬细胞的存在不受遗传或年龄控制。无菌小鼠中不存在天然细胞毒性巨噬细胞。文中讨论了天然细胞毒性的可能原因。
