Schmidt D
Epilepsy Research Group, Berlin, Germany.
Epilepsia. 1994;35 Suppl 5:S92-5. doi: 10.1111/j.1528-1157.1994.tb05979.x.
Clobazam (CLB), a 1,5-benzodiazepine, is a remarkably effective add-on drug for individual patients with refractory partial epilepsy. CLB has an excellent safety record. As with all benzodiazepines used for treating epilepsy, sedation and withdrawal effects, together with the development of tolerance, limit its usefulness. Recent efforts to prevent or reverse tolerance with intermittent administration of CLB or periodic injection of a benzodiazepine antagonist, flumazenil, are encouraging and justify further investigations.
氯巴占（CLB），一种1,5-苯二氮䓬类药物，对于难治性部分性癫痫患者是一种非常有效的附加药物。氯巴占有着出色的安全记录。与所有用于治疗癫痫的苯二氮䓬类药物一样，镇静和戒断效应，以及耐受性的产生，限制了它的效用。最近通过间歇性给予氯巴占或定期注射苯二氮䓬类拮抗剂氟马西尼来预防或逆转耐受性的努力令人鼓舞，值得进一步研究。
