Goldbohm R A, van den Brandt P A, Brants H A, van't Veer P, Al M, Sturmans F, Hermus R J
TNO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Eur J Clin Nutr. 1994 Apr;48(4):253-65.
The study was conducted to assess the validity of a self-administered 150-item food frequency questionnaire (FFQ), used in a cohort study on diet and cancer (120,852 men and women, aged 55-69).
DESIGN & SUBJECTS: The study was carried out in a subgroup of the cohort (59 men and 50 women) 2 years after the baseline FFQ was completed. A dietary record, kept over three 3-day periods, 4-5 months apart, served as reference method. To evaluate the representativeness of the study population for the entire cohort, a comparison was made with the baseline questionnaire of a random sample of the cohort.
Pearson correlation coefficients between nutrient intakes assessed by the record and the FFQ that was completed afterwards ranged from 0.40 (95% CI: 0.22-0.54) for vitamin B1 to 0.86 (95% CI: 0.80-0.90) for alcohol intake, with correlations for most nutrients between 0.6 and 0.8. Adjustment for energy intake and sex did not materially affect these correlations, except the correlation for fat intake, which changed from 0.72 to 0.52. Correlation coefficients were only slightly modified when the results were extrapolated to the cohort at large. Correction of correlation coefficients for attenuation by day-to-day variance in the record data improved them by 0.07 on average.
It is concluded that the FFQ is able to rank subjects according to intake of food groups and nutrients. Despite a better performance of validation study participants, this conclusion also applies to the cohort at large.
本研究旨在评估一份150项的自填式食物频率问卷（FFQ）的有效性，该问卷用于一项关于饮食与癌症的队列研究（涉及120852名年龄在55 - 69岁之间的男性和女性）。
该研究在基线FFQ完成2年后对队列中的一个亚组（59名男性和50名女性）进行。一份在4 - 5个月内分三个3天时间段记录的饮食记录作为参考方法。为评估该研究人群对整个队列的代表性，将其与队列随机样本的基线问卷进行了比较。
通过记录评估的营养素摄入量与之后完成的FFQ之间的Pearson相关系数范围从维生素B1的0.40（95%置信区间：0.22 - 0.54）到酒精摄入量的0.86（95%置信区间：0.80 - 0.90），大多数营养素的相关系数在0.6至0.8之间。对能量摄入和性别进行调整后，这些相关性没有实质性影响，但脂肪摄入量的相关性除外，其从0.72变为0.52。当将结果外推至整个队列时，相关系数仅有轻微改变。通过记录数据中每日差异对相关系数进行衰减校正后，平均提高了0.07。
得出的结论是，FFQ能够根据食物组和营养素的摄入量对受试者进行排名。尽管验证研究参与者的表现更好，但这一结论也适用于整个队列。
