Guerreiro J F, Figueiredo M S, Zago M A
Department of Clinical Medicine, School of Medicine, Ribeirão Preto, Brazil.
Hum Hered. 1994 May-Jun;44(3):142-9. doi: 10.1159/000154206.
We have determined the beta-globin cluster haplotypes for 80 Indians from four Brazilian Amazon tribes: Kayapó, Wayampí, Wayana-Apalaí, and Arára. The results are analyzed together with 20 Yanomámi previously studied. From 2 to 4 different haplotypes were identified for each tribe, and 7 of the possible 32 haplotypes were found in a sample of 172 chromosomes for which the beta haplotypes were directly determined or derived from family studies. The haplotype distribution does not differ significantly among the five populations. The two most common haplotypes in all tribes were haplotypes 2 and 6, with average frequencies of 0.843 and 0.122, respectively. The genetic affinities between Brazilian Indians and other human populations were evaluated by estimates of genetic distance based on haplotype data. The lowest values were observed in relation to Asians, especially Chinese, Polynesians, and Micronesians.
我们已经确定了来自巴西亚马逊地区四个部落（卡亚波、瓦扬皮、瓦亚纳 - 阿帕莱和阿拉拉）的80名印第安人的β-珠蛋白基因簇单倍型。研究结果与之前研究的20名亚诺马米人一起进行了分析。每个部落鉴定出2至4种不同的单倍型，在172条染色体样本中发现了32种可能单倍型中的7种，这些染色体的β单倍型是直接确定的或通过家系研究推导出来的。五个群体之间的单倍型分布没有显著差异。所有部落中最常见的两种单倍型是单倍型2和单倍型6，平均频率分别为0.843和0.122。基于单倍型数据的遗传距离估计评估了巴西印第安人与其他人群之间的遗传亲缘关系。与亚洲人，尤其是中国人、波利尼西亚人和密克罗尼西亚人相比，观察到的遗传距离值最低。
