Vaerman J P, Heremans J F, Bazin H, Beckers A
J Immunol. 1975 Jan;114(1 Pt 2):265-9.
An antiserum, prepared against partially reduced and alkylated rat milk SIgA, was shown to contain antibodies reacting with a rat milk protein of alpha-2 mobility, which possessed antigenic determinants common with SIaA, eluted from Sephadex G-200 at the same position as mammalian secretory components, and could be released from rat SIgA by mild reduction and alkylation. This protein, called rat secretory component, was also detected in saliva, tears and urine. Rat free secretory component (FSC) possessed antigenic determinants which were inaccessible in rat SIgA, as found in other species. In vitro, ra FSC combined with rat serum polymeric IgA or IgM, but not with monomeric IgA or IgG. These data emphasize the many similarities between the human and rat SIgA systems.
一种针对部分还原和烷基化的大鼠乳SIgA制备的抗血清，被证明含有与具有α-2迁移率的大鼠乳蛋白反应的抗体，该蛋白具有与SIaA共同的抗原决定簇，从Sephadex G-200上洗脱的位置与哺乳动物分泌成分相同，并且可以通过温和的还原和烷基化从大鼠SIgA中释放出来。这种蛋白质被称为大鼠分泌成分，在唾液、眼泪和尿液中也被检测到。与其他物种一样，大鼠游离分泌成分（FSC）具有在大鼠SIgA中无法接近的抗原决定簇。在体外，大鼠FSC与大鼠血清聚合IgA或IgM结合，但不与单体IgA或IgG结合。这些数据强调了人类和大鼠SIgA系统之间的许多相似之处。
