Sharma M R, Sharma M C, Tripathi L M, Pandey V C, Maitra S C
Department of Genetics, School of Medicine, University of Pennsylvania, Philadelphia 19104.
J Comp Pathol. 1994 Apr;110(3):313-7. doi: 10.1016/s0021-9975(08)80285-x.
Malaria infection in mice was produced by intraperitoneal inoculation of 10(6) erythrocytes parasitized with Plasmodium yoelii nigeriensis, a virulent strain of murine malaria. About one week after infection parasitaemia ranged between 60 and 80%, and 100% mortality was observed. Infected animals were killed 6 days after infection to allow the examination of brain tissue. Electron microscopical observations revealed marked damage to cerebral vascular vessel walls with separation of muscular layers, media and adventitia. The endothelial cell layer was discontinuous in places. Activated fibroblast cells producing collagen fibres were seen around the necrotic region of cerebral vasculature. Some parasitized erythrocytes were also seen attached to the endothelial cell lining. Cerebral oedema was prominent around the blood vessels.
通过腹腔接种10(6)个被约氏疟原虫（恶性疟鼠株）寄生的红细胞，在小鼠中引发疟疾感染。感染后约一周，寄生虫血症在60%至80%之间，且观察到100%的死亡率。感染动物在感染后6天被处死，以便检查脑组织。电子显微镜观察显示脑血管壁有明显损伤，肌层、中膜和外膜分离。内皮细胞层在某些部位不连续。在脑血管坏死区域周围可见产生胶原纤维的活化成纤维细胞。还可见一些被寄生的红细胞附着在内皮细胞内衬上。血管周围脑水肿明显。
