Ibiwoye M O, Howard C V, Sibbons P, Hasan M, van Velzen D
Anatomy Department, College of Medicine, University of Ibadan, Nigeria.
J Comp Pathol. 1993 Apr;108(3):303-10. doi: 10.1016/s0021-9975(08)80293-9.
Infection was induced in five rhesus monkeys (Macaca mulatta) by intravenous inoculation with a virulent strain of Plasmodium knowlesi. Approximately one week after inoculation, four of the exposed animals developed acute malaria and died or were killed when moribund after varying periods of illness. Post-mortem and light microscopical examination showed marked cerebral vascular congestion and widespread plugging of the brain capillaries and venules (microvessels) by heavily parasitized erythrocytes mixed with uninfected erythrocytes. Electronmicroscopically, the major changes seen were adherence of large numbers of parasitized erythrocytes and macrophages to swollen microvascular endothelial cells; increased numbers of fibroblasts and deposition of collagen bundles in the extracellular matrix around damaged and parasite-packed microvessels were also found in many areas. This animal model may prove useful for further investigation of the pathogenesis of cerebral malaria.
通过静脉接种恶性疟原虫的强毒株，在五只恒河猴（猕猴）中诱发感染。接种后约一周，四只受感染动物患上急性疟疾，在患病不同时期后死亡或在濒死时被处死。尸检和光学显微镜检查显示，脑血管明显充血，大量被严重寄生的红细胞与未感染的红细胞混合，广泛堵塞脑毛细血管和小静脉（微血管）。电子显微镜检查可见，主要变化是大量被寄生的红细胞和巨噬细胞粘附于肿胀的微血管内皮细胞；在许多区域还发现，受损且充满寄生虫的微血管周围的细胞外基质中，成纤维细胞数量增加，胶原束沉积。这种动物模型可能对进一步研究脑型疟疾的发病机制有用。
