Asada H, Okada N, Tei H, Yamamura T, Hashimoto K, Kondo K, Yamanishi K, Yoshikawa K
Department of Dermatology, Osaka University School of Medicine, Suita, Japan.
J Am Acad Dermatol. 1994 Aug;31(2 Pt 1):251-5. doi: 10.1016/s0190-9622(94)70157-1.
A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3+4- 8+ large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8+ lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin.
一名36岁男性体内针对爱泼斯坦-巴尔病毒（EBV）的抗体滴度很高，面部和口腔黏膜反复出现坏死性丘疹和结节。该疾病被诊断为T细胞来源的CD3 + 4 - 8 +大颗粒淋巴细胞白血病。Southern印迹分析表明，EBV DNA存在于CD8 +淋巴细胞中；在这些淋巴细胞中也观察到了EBV抗原。这些发现表明EBV潜伏感染了白血病细胞，可能在该疾病的发病机制中起作用。这是关于EBV与T细胞来源的大颗粒淋巴细胞白血病之间关联的首次报道。
