Boecker H, Kuwert T, Langen K J, Lange H W, Czech N, Ziemons K, Herzog H, Shikare S, Weindl A, Feinendegen L E
Institute of Medicine, Research Center Jülich GmbH, Germany.
J Comput Assist Tomogr. 1994 Jul-Aug;18(4):542-8. doi: 10.1097/00004728-199407000-00005.
It is the aim of this study to compare the performance of 99mTc-d,l-hexamethylpropyleneamine oxime (HMPAO) SPECT with that of [18F]fluorodeoxyglucose (FDG) PET in detecting striatal dysfunction as it occurs in Huntington disease (HD).
For the determination of regional cerebral glucose consumption, the PET camera PC-4096 was used; the cerebral uptake of HMPAO was measured using the three-head SPECT camera TRIAD. Eight patients with manifest HD, seven subjects at risk for HD, and nine normal individuals were included in the study. In both modalities data evaluation was performed using caudate-to-whole-slice (C/S) ratios. The patients' data were compared to 95% confidence intervals determined in the nine controls.
The PET and SPECT C/S values correlated significantly (n = 24; r = 0.87; p < 0.0001). The C/S values were significantly reduced in PET in all eight and in SPECT in seven of the eight HD patients studied. Five of the seven at-risk subjects had normal C/S values in PET and SPECT, one showed reduced C/S values in both diagnostic methods, and the remaining at-risk individual showed a reduced C/S value in PET only. Thus, concordant results between PET and SPECT were obtained in seven of eight patients and six of seven at-risk subjects studied, corresponding to an 87% accuracy of SPECT in the detection of striatal dysfunction as compared to the "gold standard" PET.
With use of a multidetector camera, HMPAO-SPECT comes near the performance of FDG-PET in the diagnosis of striatal dysfunction as it occurs in HD.
本研究旨在比较99mTc - d，l - 六甲基丙烯胺肟（HMPAO）单光子发射计算机断层扫描（SPECT）与[18F]氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）在检测亨廷顿病（HD）中出现的纹状体功能障碍方面的表现。
为测定局部脑葡萄糖代谢，使用了PET相机PC - 4096；使用三头SPECT相机TRIAD测量HMPAO的脑摄取量。本研究纳入了8例显性HD患者、7例HD高危受试者和9名正常个体。两种检查方式均使用尾状核与全层（C/S）比值进行数据评估。将患者的数据与9名对照者确定的95%置信区间进行比较。
PET和SPECT的C/S值显著相关（n = 24；r = 0.87；p < 0.0001）。在研究的8例HD患者中，所有8例患者的PET的C/S值显著降低，8例中有7例患者的SPECT的C/S值显著降低。7例高危受试者中有5例在PET和SPECT中的C/S值正常，1例在两种诊断方法中均显示C/S值降低，其余1例高危个体仅在PET中显示C/S值降低。因此，在研究的8例患者中有7例以及7例高危受试者中有6例在PET和SPECT之间获得了一致的结果，与“金标准”PET相比，SPECT检测纹状体功能障碍的准确率为87%。
使用多探测器相机时，HMPAO - SPECT在诊断HD中出现的纹状体功能障碍方面的表现接近FDG - PET。
