Martin W R, Hoskinson M, Kremer B, Maguire C, McEwan A
Department of Medicine, Neurology, University of Alberta, Edmonton, Canada.
J Neuroimaging. 1995 Oct;5(4):227-32. doi: 10.1111/jon199554227.
Functional neuroimaging with positron emission tomography previously demonstrated reduced caudate glucose metabolism in virtually all symptomatic patients with Huntington's disease (HD). Single-photon emission computed tomography studies of brain blood flow also have shown caudate abnormalities in patients with HD. The present study compared these two functional imaging modalities in 6 patients with HD who had been symptomatic for fewer than 5 years. All patients had significantly impaired caudate-thalamus and caudate-whole-slice glucose metabolism ratios as measured by positron emission tomography. However, only 3 had clearly abnormal caudate-thalamus activity ratios and 2 had clearly abnormal caudate-whole-slice ratios on single-photon emission computed tomography. These findings indicate that single-photon emission computed tomography imaging of caudate blood flow is a less sensitive indicator of caudate dysfunction in early HD than is positron emission tomography imaging of caudate glucose metabolism.
正电子发射断层扫描的功能神经成像先前已证实，几乎所有有症状的亨廷顿病（HD）患者的尾状核葡萄糖代谢均降低。脑血流的单光子发射计算机断层扫描研究也显示HD患者存在尾状核异常。本研究比较了6例症状出现少于5年的HD患者的这两种功能成像方式。通过正电子发射断层扫描测量，所有患者的尾状核-丘脑和尾状核-全层葡萄糖代谢率均显著受损。然而，单光子发射计算机断层扫描显示，只有3例患者的尾状核-丘脑活性比明显异常，2例患者的尾状核-全层比明显异常。这些发现表明，与尾状核葡萄糖代谢的正电子发射断层扫描成像相比，尾状核血流的单光子发射计算机断层扫描成像在早期HD中对尾状核功能障碍的指示敏感性较低。
