Glosser G, Wolfe N, Albert M L, Lavine L, Steele J C, Calne D B, Schoenberg B S
Department of Neurology, Boston University School of Medicine, Massachusetts.
J Am Geriatr Soc. 1993 Sep;41(9):931-9. doi: 10.1111/j.1532-5415.1993.tb06758.x.
Validation of a new instrument for screening dementia, the Cross Cultural Cognitive Examination (CCCE), is described.
Criterion and concurrent validation and cross-cultural comparison of a new instrument.
All individuals over the age of 40 in a village in southern Guam participated in a door-to-door survey. Alzheimer's and Parkinson's Disease patients and healthy controls aged 40-90 participated in the US mainland study.
The CCCE was administered to all subjects. Effects of age, language, education, and gender on test performances and social-cultural differences were assessed. Concurrent validation of the test with respect to other well accepted screening instruments was determined.
High specificity (> 94%) and sensitivity (> 99%) for detecting dementia were found in Guam and US mainland samples, and these were not biased by differences in gender, linguistic preference, education, or cultural background. Sensitivity and specificity of the CCCE matched or exceeded that of already accepted dementia screening instruments.
These validation studies support the usefulness of the CCCE for identifying patients with generalized dementia, rather than focal types of cognitive impairment, quickly and reliably in cross-cultural neuroepidemiological research.
描述一种用于筛查痴呆症的新工具——跨文化认知检查（CCCE）的验证情况。
对一种新工具进行标准和同时效度验证以及跨文化比较。
关岛南部一个村庄所有40岁以上的人参与了挨家挨户的调查。40至90岁的阿尔茨海默病和帕金森病患者以及健康对照者参与了美国大陆的研究。
对所有受试者进行CCCE测试。评估年龄、语言、教育程度和性别对测试表现的影响以及社会文化差异。确定该测试与其他公认的筛查工具的同时效度。
在关岛和美国大陆样本中发现CCCE检测痴呆症具有高特异性（>94%）和高敏感性（>99%），且不受性别、语言偏好、教育程度或文化背景差异的影响。CCCE的敏感性和特异性与已被接受的痴呆症筛查工具相当或更高。
这些验证研究支持CCCE在跨文化神经流行病学研究中快速、可靠地识别患有广泛性痴呆而非局灶性认知障碍类型患者的有用性。
