吡喹酮类似物治疗肠道绦虫和吸虫感染的临床试验结果分析。1. 肠道绦虫感染（阔节裂头绦虫病、带绦虫病、微小膜壳绦虫病）的治疗
[An analysis of the results of clinical trials of praziquantel analogs in intestinal cestode and trematode infections. 1. The treatment of intestinal cestode infections (diphyllobothriasis, taeniasis, hymenolepiasis)].
作者信息
Bronshteĭn A M, Mel'nikova L I, Firsova R A, Legon'kov Iu A
出版信息
Med Parazitol (Mosk). 1993 May-Jun(3):27-9.
The studies have demonstrated a high efficacy of prasiquantel in therapy of enteric cestodiases. No differences in the efficacy and tolerance of prasiquantel analogs manufactured by various pharmaceutic firms (azinox, CIS; pikiton, China; biltricide, Bayer, India; cesol, Merk, India; cisticide, Merk India) were detected. Prasiquantel single dose (15 mg/kg) efficacies in diphyllobothriasis, taeniarhynchiasis, and taeniasis made up 91.4, 98.5, and 100%, respectively. In hymenolepiasis the efficacy of a total dose (40 and 50 mg/kg given twice with a 10-day interval) was 88.9%.
研究表明吡喹酮治疗肠道绦虫病疗效显著。未检测到各制药公司生产的吡喹酮类似物（阿嗪诺克斯，独联体；吡喹酮，中国；肠虫清，拜耳，印度；赛索，默克，印度；西斯蒂西德，默克印度）在疗效和耐受性方面存在差异。吡喹酮单剂量（15毫克/千克）治疗阔节裂头绦虫病、牛带绦虫病和猪带绦虫病的有效率分别为91.4%、98.5%和100%。在微小膜壳绦虫病中，总剂量（40和50毫克/千克，间隔10天给药两次）的有效率为88.9%。
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