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[对西伯利亚中部蜱传脑炎自然疫源地小型哺乳动物进行血清学检查的尝试]

[An attempt at the serological examination of small mammals in a natural focus of tick-borne encephalitis in central Siberia].

作者信息

Kislenko G S, Korotkov Iu S, Chunikhin S P, Karavanov A S

出版信息

Med Parazitol (Mosk). 1993 May-Jun(3):34-8.

PMID:8041318
Abstract

Studies of blood serum samples from Asian mice from a natural focus of tick-borne encephalitis (TBE) in the Krasnoyarsk district, in which agent strains of medium peripheral activity for white mice predominated, in the hemagglutination inhibition test have given negative results. At the same time murine sera were detected with nonspecific inhibitors to TBE virus in low titers (1:10 to 1:20), this being confirmed by enzyme immunoassay. Of the tested in 1988-1991 1047 mice of 11 species the share of sera with nonspecific inhibitors (and, consequently, positive ones) has made up 3.3 +/- 1.9/0.0 for asian mice (6.2 +/- 3.3/0.0 for males and 0.0/0.0 females), 1.4 +/- 1.4/2.8 +/- 2.0 in striped field mice (0.0/0.0 males and 3.2 +/- 3.2/6.4 +/- 4.5 females), and 0.5 +/- 0.3/5.7 +/- 1.0 in red-backed mice (0.3 +/- 0.3/6.3 +/- 1.4 males and 0.7 +/- 0.5/5.1 +/- 1.3 females).

摘要

对克拉斯诺亚尔斯克地区蜱传脑炎(TBE)自然疫源地亚洲小鼠血清样本进行的研究中,在血凝抑制试验里,以对白鼠具有中等外周活性的病原体菌株为主的样本给出了阴性结果。同时,检测到鼠血清中存在低滴度(1:10至1:20)的TBE病毒非特异性抑制剂,酶免疫测定证实了这一点。在1988 - 1991年测试的11个物种的1047只小鼠中,亚洲小鼠血清中含有非特异性抑制剂(因此为阳性)的比例为3.3±1.9/0.0(雄性为6.2±3.3/0.0,雌性为0.0/0.0),条纹田鼠为1.4±1.4/2.8±2.0(雄性为0.0/0.0,雌性为3.2±3.2/6.4±4.5),红背鼠为0.5±0.3/5.7±1.0(雄性为0.3±0.3/6.3±1.4,雌性为0.7±0.5/5.1±1.3)。

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