Lundeberg T, Uvnäs-Moberg K, Agren G, Bruzelius G
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Neurosci Lett. 1994 Mar 28;170(1):153-7. doi: 10.1016/0304-3940(94)90262-3.
The existence of neural opioid-mediated networks that are specific for the modulation of nociception is well established. Parallel non-opioid pathways exist, but their underlying physiology is little known. We now report that oxytocin administered intraperitoneally to rats, and intraperitoneally or intracisternally to mice has an anti-nociceptive effect, which is related to the activation of descending anti-nociceptive pathways. This anti-nociceptive effect can be reversed by an oxytocin antagonist but not by the opioid antagonist naloxone. The anti-nociceptive effect of oxytocin is not directly dependent on the activation of serotonergic pathways or to changes in temperature. Our data indicate that the oxytocinergic system has a modulatory function on nociception.
神经阿片类物质介导的、专门用于调节伤害感受的神经网络的存在已得到充分证实。并行的非阿片类通路也存在，但其潜在生理学机制鲜为人知。我们现在报告，腹腔注射给大鼠以及腹腔内或脑池内注射给小鼠的催产素具有抗伤害感受作用，这与下行抗伤害感受通路的激活有关。这种抗伤害感受作用可被催产素拮抗剂逆转，但不能被阿片类拮抗剂纳洛酮逆转。催产素的抗伤害感受作用并不直接依赖于5-羟色胺能通路的激活或温度变化。我们的数据表明，催产素能系统对伤害感受具有调节功能。
