Nelson P T, Greenberg S G, Saper C B
Brain Research Institute, University of Chicago, IL 60637.
Neurosci Lett. 1994 Mar 28;170(1):187-90. doi: 10.1016/0304-3940(94)90270-4.
Neurofibrillary degeneration, including neurofibrillary tangles (NFTs) and neuritic plaques, is an important pathological hallmark of Alzheimer's disease (AD). Unfortunately, no practical animal model of neurofibrillary degeneration has been described. We report here the presence of structures in the cerebral cortex of sheep, Ovis aries, that resemble Alzheimer NFTs and neuritic plaques. NFT-like structures and clusters of degenerating neurites are stained by silver impregnation and thioflavin-S, and are immunoreactive with antibodies against tau microtubule-associated proteins. Viewed under the electron microscope, tau-immunoreactive tangles consist of paired helical filaments. Naturally occurring neurofibrillary structures in sheep cortex provide a model for studying the pathobiology of Alzheimer's disease.
神经纤维变性，包括神经纤维缠结（NFTs）和神经炎斑块，是阿尔茨海默病（AD）的重要病理标志。遗憾的是，尚未有实用的神经纤维变性动物模型被描述。我们在此报告，在绵羊（Ovis aries）的大脑皮质中存在类似于阿尔茨海默病NFTs和神经炎斑块的结构。NFT样结构和退化神经突簇被银浸染法和硫黄素-S染色，并且与抗tau微管相关蛋白的抗体发生免疫反应。在电子显微镜下观察，tau免疫反应性缠结由双螺旋丝组成。绵羊皮质中自然存在的神经纤维结构为研究阿尔茨海默病的病理生物学提供了一个模型。
