Cavenee M R, Cox S M, Mason R, Cunningham F G
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas.
Obstet Gynecol. 1994 Aug;84(2):252-4.
To determine whether antepartum pyelonephritis causes an acute or delayed alteration in erythropoietin production.
Serum erythropoietin concentrations were determined prospectively using an enzyme-linked immunosorbent technique in 36 pregnant women admitted to Parkland Hospital with pyelonephritis. Healthy nonanemic pregnant women served as controls.
Serum erythropoietin levels in women with antepartum pyelonephritis were not different from those measured in normal pregnant women. Specifically, there were no differences in erythropoietin levels in women who had anemia at admission (n = 6; 13.8 mU/mL), hemolysis (15.4 versus 12.9 mU/mL), or renal insufficiency (14.5 versus 12.9 mU/mL) secondary to renal infection as compared to controls.
We conclude that antepartum pyelonephritis does not alter erythropoietin production either acutely or within several days of infection. Because erythropoietin production was not decreased, we suggest that hemolysis is the major factor contributing to anemia associated with renal infection.
确定产前肾盂肾炎是否会导致促红细胞生成素产生急性或延迟改变。
采用酶联免疫吸附技术前瞻性地测定了36例因肾盂肾炎入住帕克兰医院的孕妇血清促红细胞生成素浓度。健康的非贫血孕妇作为对照。
产前肾盂肾炎女性的血清促红细胞生成素水平与正常孕妇的测量值无差异。具体而言，入院时贫血（n = 6；13.8 mU/mL）、溶血（15.4对12.9 mU/mL）或继发于肾脏感染的肾功能不全（14.5对12.9 mU/mL）的女性促红细胞生成素水平与对照组相比无差异。
我们得出结论，产前肾盂肾炎不会在感染后急性或数天内改变促红细胞生成素的产生。由于促红细胞生成素的产生没有减少，我们认为溶血是导致与肾脏感染相关贫血的主要因素。
