Chen M F, Hsu H C, Chen W J, Lee C M, Wu C C, Liau C S, Lee Y T
Department of Internal Medicine (Cardiology), National Taiwan University Hospital, Taipei.
Prostaglandins. 1994 Apr;47(4):307-17. doi: 10.1016/0090-6980(94)90025-6.
We studied the changes in lipid peroxidation and prostanoid metabolism in short-term coronary occlusion-reperfusion in controls and those rabbits (11 in each group) fed a 1% high cholesterol diet with or without 10% fish oil supplementation for one week. Acute coronary occlusion for 10 minutes was induced by ligating the marginal branch of the left circumflex coronary artery. The vessels were then reperfused for 1 hour. The cholesterol and fish oil treated rabbits had the lowest malondialdehyde levels both in the ischemic and non-ischemic (normal) areas, the least increase of malondialdehyde level in the ischemic area, and the highest 6-keto-PGF1 alpha/thromboxane B2 ratio in the non-ischemic area after reperfusion among the 3 groups. These rabbits had the highest myocardial superoxide dismutase levels both in the ischemic and normal areas, and the least decrease of superoxide dismutase level in the ischemic area. These data suggest that rabbits fed a high cholesterol diet with fish oil supplementation had an attenuated lipid peroxidation, which reflected a reduced free radical generation during a short-term coronary occlusion followed by reperfusion.
我们研究了对照组以及两组兔子（每组11只）在短期冠状动脉闭塞-再灌注过程中脂质过氧化和前列腺素代谢的变化。这两组兔子均喂食1%高胆固醇饮食，其中一组额外补充10%鱼油，另一组不补充，为期一周。通过结扎左旋冠状动脉的边缘支诱导急性冠状动脉闭塞10分钟。然后血管再灌注1小时。在三组中，胆固醇和鱼油处理组的兔子在缺血和非缺血（正常）区域的丙二醛水平最低，缺血区域丙二醛水平的增加最少，再灌注后非缺血区域的6-酮-前列腺素F1α/血栓素B2比值最高。这些兔子在缺血和正常区域的心肌超氧化物歧化酶水平最高，缺血区域超氧化物歧化酶水平的下降最少。这些数据表明，喂食补充鱼油的高胆固醇饮食的兔子脂质过氧化减弱，这反映了在短期冠状动脉闭塞随后再灌注期间自由基生成减少。
