Graffagnino C, Gasecki A P, Doig G S, Hachinski V C
Department of Medicine, Duke University Medical Center, Durham, NC.
Stroke. 1994 Aug;25(8):1599-604. doi: 10.1161/01.str.25.8.1599.
The role of genetics in cerebrovascular disease remains controversial. The purpose of this study was to assess the influence of family history on atherothrombotic infarction or transient ischemic attack.
Ninety patients with stroke or transient ischemic attack and 90 age- and sex-matched community control subjects were studied prospectively. Medical and family histories were obtained from all subjects, and a complete physical examination was performed.
Eighty-five patients and 86 control subjects knew their family history for ischemic heart disease and stroke. A positive history for ischemic heart disease was present in 62 (73%) of the patients and 46 (53%) of the control subjects (P = .019), and a positive family history for stroke was present in 38 (47%) of the patients and 21 (24%) of the control subjects (P = .014).
Although a positive vascular family history was not an independent risk factor in a multivariate analysis, it was an excellent marker of the presence of other established vascular risk factors. Personal histories of ischemic heart disease, hypertension, and hyperlipidemia were found to be significant independent risk factors for stroke.
遗传学在脑血管疾病中的作用仍存在争议。本研究的目的是评估家族史对动脉粥样硬化性血栓形成性梗死或短暂性脑缺血发作的影响。
对90例中风或短暂性脑缺血发作患者以及90名年龄和性别匹配的社区对照受试者进行前瞻性研究。从所有受试者处获取病史和家族史，并进行全面的体格检查。
85例患者和86名对照受试者了解他们的缺血性心脏病和中风家族史。62例（73%）患者有缺血性心脏病阳性家族史，46例（53%）对照受试者有该家族史（P = 0.019）；38例（47%）患者有中风阳性家族史，21例（24%）对照受试者有该家族史（P = 0.014）。
虽然在多变量分析中阳性血管家族史不是独立的危险因素，但它是其他已确定的血管危险因素存在的良好标志。发现缺血性心脏病、高血压和高脂血症的个人病史是中风的重要独立危险因素。
