Gallerani M, Trappella G, Manfredini R, Pasin M, Napolitano M, Migliore A
Emergency Department of St. Anna Hospital, Ferrara, Italy.
Acta Neurol Scand. 1994 Apr;89(4):280-6. doi: 10.1111/j.1600-0404.1994.tb01681.x.
Hypothesis of the circannual and circadian variation in onset of intracerebral haemorrhage (CH) was verified, by means of single cosinor method and chi-square test for goodness of fit, in 161 consecutive patients (94 men and 67 women) admitted into the Institute of Neurosurgery of Ferrara Hospital, Italy, over 9 years. The majority of CH occurred in the morning between 06.00 AM and 12.00 noon (36.7% of cases, p < 0.001); when considering the specific anatomical sites, typical supratentorial haemorrhages showed a similar pattern (37.4%, p = 0.01). A similar morning behavior was found when considering subgroups by sex (men 36.2%, women 37.3%), age > or = 60 years (42.5%), no presence of hypertension (39.7%), no presence of diabetes mellitus (33.3%) and non-smokers (30.4%). The results by cosinor analysis yielded a circadian rhythmicity both for total sample and, for the men's subgroup, with a morning peak at 11.44 and 11.25, respectively. For women, however, spectral analysis found a significant ultradian cycle, having a period of 12 h (p = 0.01). A circannual periodicity, with a prevalent peak in February, was found for total sample and males subgroups, too. The results of this study confirm that intracerebral haemorrhages present a characteristic circadian and circannual pattern in onset.
采用单余弦分析法和卡方拟合优度检验，对意大利费拉拉医院神经外科9年间收治的161例连续患者（94例男性和67例女性）进行研究，验证脑出血（CH）发病的年周期和昼夜节律变化假说。大多数脑出血发生在上午6点至中午12点之间（占病例的36.7%，p<0.001）；考虑特定解剖部位时，典型的幕上出血呈现类似模式（37.4%，p = 0.01）。按性别（男性36.2%，女性37.3%）、年龄≥60岁（42.5%）、无高血压（39.7%）、无糖尿病（33.3%）和非吸烟者（30.4%）划分亚组时，发现了类似的上午发病情况。余弦分析结果显示，总样本以及男性亚组均存在昼夜节律，上午高峰分别出现在11.44和11.25。然而，对于女性，频谱分析发现一个显著的超日周期，周期为12小时（p = 0.01）。总样本和男性亚组也发现了年周期，2月出现普遍高峰。本研究结果证实，脑出血在发病方面呈现出特征性的昼夜和年周期模式。
