Hildebrandt G, Scheidhauer K, Luyken C, Schicha H, Klug N, Dahms P, Krisch B
Department of Neurosurgery, University of Köln, Federal Republic of Germany.
Acta Neurochir (Wien). 1994;126(2-4):63-71. doi: 10.1007/BF01476412.
The recent availability of isotope-labelled somatostatin analogues has allowed one to detect somatostatin receptors in normal tissue as well as in endocrine or non-endocrine cranial tumours. The purpose of the present study was to establish the value of somatostatin receptor scintigraphy using an 111Indium-labelled somatostatin analogue, octreotide, in the diagnostic work-up of meningioma patients. Twenty-two patients (16 women, 6 men, aged from 19-70 years) with newly diagnosed, residual or recurrent cranial meningiomas were examined. 111Indium-labelled DTPA-octreotide was injected i.v.. Planar and tomographic images were obtained with a gamma camera 4-6, and 24 hours after injection. In all of the meningiomas studied a high density of somatostatin receptors was detected by scintigraphy. No false negative test result was found. Due to this, a 100% predictive value of a negative test was calculated. However, when the tumours were taken in culture differing staining intensity could be seen in the light- and electron microscopic level even on individual cells of a single culture when silver intensified somatostatin-gold was used as ligand. We conclude, that in vivo somatostatin receptor scintigraphy may aid in the pre-operative differential diagnosis of skull base tumours.
近期，同位素标记的生长抑素类似物的出现，使得人们能够在正常组织以及内分泌或非内分泌性颅部肿瘤中检测生长抑素受体。本研究的目的是确定使用111铟标记的生长抑素类似物奥曲肽进行生长抑素受体闪烁扫描在脑膜瘤患者诊断检查中的价值。对22例新诊断、残留或复发的颅部脑膜瘤患者（16例女性，6例男性，年龄19 - 70岁）进行了检查。静脉注射111铟标记的二乙三胺五乙酸 - 奥曲肽。在注射后4 - 6小时以及24小时，用γ相机获取平面和断层图像。在所有研究的脑膜瘤中，闪烁扫描检测到高密度的生长抑素受体。未发现假阴性检测结果。因此，计算出阴性检测的预测值为100%。然而，当肿瘤进行培养时，即使在单一培养物的单个细胞上，在光学和电子显微镜水平使用银增强的生长抑素 - 金作为配体时，也能看到不同的染色强度。我们得出结论，体内生长抑素受体闪烁扫描可能有助于颅底肿瘤的术前鉴别诊断。
