Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R
Science. 1973 Jan 5;179(4068):77-9. doi: 10.1126/science.179.4068.77.
A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.
从绵羊下丘脑分离出一种肽，其浓度为1×10⁻⁹M时，可在体外抑制大鼠或人生长激素的免疫反应性分泌，在大鼠体内也具有类似活性。其结构为H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH。合成复制品具有生物活性。
