Hannallah R S, Kaplan R F
Department of Anesthesiology, Children's National Medical Center, Washington, DC 20010.
Anesthesiology. 1994 Jul;81(1):99-103; discussion 28A. doi: 10.1097/00000542-199407000-00015.
Lack of complete jaw relaxation after a halothane-succinylcholine sequence has been described in the literature. To date, however, most existing studies are retrospective, and lack agreement on the magnitude and incidence of this phenomenon. This prospective study examined the incidence and degree of incomplete jaw relaxation in 500 children who were given intravenous succinylcholine during halothane anesthesia.
Five hundred consecutive unmedicated children received a minimum dose of 2 mg/kg intravenous succinylcholine after induction of anesthesia with halothane. The degree of jaw relaxation was assessed 45-60 s later by the same observer using a standardized clinical scale. The degree of relaxation was correlated with the type of surgical procedure, and the presence and intensity of fasciculations.
Complete relaxation (mouth opened easily and fully) occurred in 95.4% of study patients. Incomplete relaxation (firm manual separation required to open the mouth fully) was seen in 4.4% of the patients. One child (0.2%) had masseter muscle rigidity (mouth could not be fully opened but intubation possible). There were no incidents of trismus (teeth clamped shut and intubation via direct visualization impossible). The incidence of incomplete relaxation and masseter muscle rigidity did not correlate with the presence or degree of fasciculations or the type of surgical procedure. There were no clinical signs of a hypermetabolic state or myoglobinuria in any patient.
Incomplete jaw relaxation after a halothane-succinylcholine sequence is not uncommon in children, and is considered a normal response.
文献中已描述了氟烷 - 琥珀酰胆碱诱导后下颌未完全松弛的情况。然而,迄今为止,大多数现有研究都是回顾性的,并且对于这一现象的严重程度和发生率尚未达成共识。这项前瞻性研究调查了500例在氟烷麻醉期间接受静脉注射琥珀酰胆碱的儿童下颌未完全松弛的发生率和程度。
500例连续未用药的儿童在氟烷诱导麻醉后接受了至少2mg/kg的静脉注射琥珀酰胆碱。45 - 60秒后,由同一名观察者使用标准化临床量表评估下颌松弛程度。松弛程度与手术类型、肌束震颤的有无及强度相关。
95.4%的研究患者出现完全松弛(口腔易于且完全张开)。4.4%的患者出现不完全松弛(需用力手动分开才能完全张开口腔)。1名儿童(0.2%)出现咬肌强直(口腔无法完全张开但可插管)。未发生牙关紧闭(牙齿紧闭,无法直视下插管)情况。不完全松弛和咬肌强直的发生率与肌束震颤的有无或程度以及手术类型无关。所有患者均未出现高代谢状态或肌红蛋白尿的临床体征。
氟烷 - 琥珀酰胆碱诱导后下颌未完全松弛在儿童中并不罕见,被认为是一种正常反应。