新型苯环取代的4-吗啉基-1-苯硫基-2-丁酮[曼尼希碱]的合成及其抗癌活性
Synthesis and anticancer activity of new phenyl-ring substituted 4-morpholino-1-phenylthio-2-butanones [Mannich bases].
作者信息
Siatra-Papastaikoudi T, Tsotinis A, Chinou I, Roussakis C
机构信息
Department of Pharmaceutical Chemistry and of Pharmacognosy, University of Athens, Greece.
出版信息
Farmaco. 1994 Mar;49(3):221-3.
PMID:8043174
Abstract
The preparation of phenyl-ring substituted 4-morpholino-1-phenylthio-2-butanones 4a-e is described. These compounds were evaluated against P-388 leukemia and human cancer rhinopharynx KB cells in vitro; some compounds were found to exhibit activity against these cell lines.
摘要
本文描述了苯环取代的4-吗啉基-1-苯硫基-2-丁酮4a - e的制备方法。这些化合物在体外针对P - 388白血病细胞和人鼻咽癌KB细胞进行了评估；发现一些化合物对这些细胞系具有活性。
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