Chang C W, Lien I N
Department of Physical Medicine and Rehabilitation, National Taiwan University School of Medicine, Taipei, Republic of China.
Am J Phys Med Rehabil. 1994 Jul-Aug;73(4):275-9. doi: 10.1097/00002060-199407000-00009.
The influence of pulsed magnetic stimulation on denervated muscles was investigated in this study. Of 24 rats divided into three groups for experiment, 8 rats served as control; 16 rats with bilaterally severed sciatic nerves were divided into two groups for different modes of stimulation. Magnetic stimulation with a high power output that induced an intensive contraction of muscle was applied at one side-denervated gastrocnemius muscle for 1 mo in a group of rats; electric stimulation with high intensity at 6 Hz frequency and 1-ms pulse duration served as a contrast in the other group. Muscular weight, volume, fiber diameter and percentage of fiber types were measured after the experiment. A significant retardation of weight loss in denervated muscles via magnetic stimulation (P < 0.05) was confirmed by observed results. Type II fiber atrophy was retarded in denervated muscles by magnetic stimulation as well as in denervated muscles via electric stimulation. Magnetic stimulation, used as a method that induces muscular activity, was verified in this study as being capable of retarding denervated muscular atrophy. Its benefits of painless stimulation as well as deeply activated muscular contraction could be expected to function as a new model for rehabilitation of paralyzed muscles.
本研究探讨了脉冲磁刺激对失神经支配肌肉的影响。将24只大鼠分为三组进行实验，其中8只作为对照组；16只双侧坐骨神经切断的大鼠分为两组接受不同的刺激模式。一组大鼠对一侧失神经支配的腓肠肌施加高功率输出的磁刺激，诱导肌肉强烈收缩，持续1个月；另一组以6 Hz频率和1 ms脉冲持续时间的高强度电刺激作为对照。实验结束后测量肌肉重量、体积、纤维直径和纤维类型百分比。观察结果证实，磁刺激可显著延缓失神经支配肌肉的重量减轻（P < 0.05）。磁刺激以及电刺激均可延缓失神经支配肌肉中II型纤维的萎缩。本研究证实，作为一种诱导肌肉活动的方法，磁刺激能够延缓失神经支配肌肉的萎缩。其无痛刺激以及深度激活肌肉收缩的优点有望成为瘫痪肌肉康复的新模式。
