Siroki O, Institoris L, Tatar E, Desi I
Department of Public Health, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary.
Hum Exp Toxicol. 1994 May;13(5):337-43. doi: 10.1177/096032719401300509.
The toxicity of a new pyrethroid pesticide Supercypermethrin Forte (SCMF) was studied in male CFLP mice using classic toxicological (body weight, organ weights) and haematological (white blood cell count, haematocrit, nucleated cell content of femoral bone marrow) methods and immune function tests (PFC assay, DTH reaction). Four weeks of oral treatment in a 5 days per week system at doses of 1/10, 1/20, or 1/40 x LD50 did not cause evaluable changes in the measured parameters. When single calculated LD20, LD10, or LD5 doses of SCMF were administered on different days before termination to different groups of mice the two higher doses caused a time- and dose-dependent decrease in the splenic PCF number. Apart from some temporary toxic signs and an increase of haematocrit at the top dose the other examined parameters did not show evaluable changes. Under these experimental conditions toxic changes appeared only at the high dose range and, of those applied, the PFC assay proved to be the most sensitive method for detecting the toxicity of SCMF.
使用经典毒理学方法（体重、器官重量）、血液学方法（白细胞计数、血细胞比容、股骨骨髓有核细胞含量）和免疫功能测试（空斑形成细胞试验、迟发型超敏反应），在雄性CFLP小鼠中研究了一种新型拟除虫菊酯农药高效氯氰菊酯（SCMF）的毒性。在每周给药5天的系统中，以1/10、1/20或1/40×LD50的剂量进行四周口服治疗，未导致所测参数出现可评估的变化。当在处死前不同的日子给不同组的小鼠单次给予计算出的LD20、LD10或LD5剂量的SCMF时，两个较高剂量导致脾空斑形成细胞数量呈时间和剂量依赖性减少。除了一些暂时的中毒体征以及最高剂量时血细胞比容升高外，其他检测参数未显示出可评估的变化。在这些实验条件下，毒性变化仅出现在高剂量范围，在所应用的方法中，空斑形成细胞试验被证明是检测SCMF毒性最敏感的方法。
