白种人和韩国精神分裂症患者血清可溶性白细胞介素-2受体增加。

Increased serum soluble interleukin-2 receptors in Caucasian and Korean schizophrenic patients.

作者信息

Rapaport M H, McAllister C G, Kim Y S, Han J H, Pickar D, Nelson D L, Kirch D G, Paul S M

机构信息

Department of Psychiatry, University of California, San Diego.

出版信息

Biol Psychiatry. 1994 May 15;35(10):767-71. doi: 10.1016/0006-3223(94)91137-1.

DOI:10.1016/0006-3223(94)91137-1

PMID:8043705

Abstract

Recent studies have identified immunologic abnormalities in some schizophrenic subjects. This experiment replicates previous findings that serum soluble interleukin-2 receptors (SIL-2Rs) are elevated in schizophrenic patients, and is the first study to describe this phenomenon in non-Caucasian patients. Despite differences between Korean and Caucasian schizophrenic patients in absolute serum SIL-2R levels, both groups were significantly elevated when compared with their respective ethnic control groups (477 +/- 171 U/ml versus 354 +/- 172 U/ml and 763 +/- 347 U/ml versus 567 +/- 231 U/ml, respectively). Neither age, gender, medication status, nor duration of illness correlated with SIL-2R levels. These findings are further evidence that immune activation is present, regardless of ethnic origin, in some schizophrenic patients.

摘要

近期研究已在部分精神分裂症患者中发现了免疫异常情况。本实验重复了先前的研究结果，即精神分裂症患者血清可溶性白细胞介素-2受体（SIL-2Rs）水平升高，并且是首次在非白种人患者中描述这一现象的研究。尽管韩国精神分裂症患者与白种精神分裂症患者的血清SIL-2R绝对水平存在差异，但与各自的种族对照组相比，两组患者的该水平均显著升高（分别为477±171 U/ml对354±172 U/ml以及763±347 U/ml对567±231 U/ml）。年龄、性别、用药状况及病程均与SIL-2R水平无关。这些发现进一步证明，部分精神分裂症患者无论种族来源，均存在免疫激活现象。