Kliushnenkova E N, Lutskaia T D, Golenkov A K, Malaĭtsev V V
Biull Eksp Biol Med. 1993 May;115(5):507-10.
Constitutive and lipopolysaccharide (LPS)--induced production of interleukin (IL)-1 and IL-6 have been investigated in peripheral blood (PB) and bone marrow (BM) of patients with multiple myeloma (MM) and PB of health donors. The level of these cytokines has been higher in MM in comparison with norm. Monocytes of PB of patients with MM have been more stimulated by LPS than those of health people. When adherent and nonadherent cells have been cultured apart, there not have not been any differences in constitutive IL-6 production between compared groups. The important role of cell-cell interactions in regulation of IL-6 production is proposed. High level of IL-6 in BM of patients with MM is conditioned by mutual stimulation of adherent and nonadherent cells.
对多发性骨髓瘤（MM）患者的外周血（PB）和骨髓（BM）以及健康供体的PB中组成型和脂多糖（LPS）诱导的白细胞介素（IL）-1和IL-6生成进行了研究。与正常情况相比，MM患者中这些细胞因子的水平更高。MM患者PB中的单核细胞比健康人PB中的单核细胞对LPS的刺激更敏感。当贴壁细胞和非贴壁细胞分开培养时，比较组之间组成型IL-6生成没有差异。提出了细胞间相互作用在IL-6生成调节中的重要作用。MM患者BM中IL-6的高水平是由贴壁细胞和非贴壁细胞的相互刺激所决定的。
