血管加压素类似物[d(CH2)5(1),Tyr(Me)2]AVP对实验性失忆大鼠记忆过程的影响。
The effect of vasopressin analogue [d(CH2)5(1),Tyr(Me)2]AVP on memory process in rats with experimental amnesia.
作者信息
Car H, Borawska M, Wiśniewski K
机构信息
Department of Pharmacology, Medical Academy, Białystok, Poland.
出版信息
Acta Neurobiol Exp (Wars). 1995;55(3):207-11. doi: 10.55782/ane-1995-1077.
PMID:8553914
Abstract
We investigated the effect of a single 2 micrograms dose of vasopressin (AVP) analogue [(CH2)5(1),Tyr(Me)2]AVP on the processes of retrieval of conditioned reflexes in rats with experimentally induced amnesia. The models used were: electroconvulsive shock (ECS) and hypoxia. It severely impaired the memory processes. The AVP analogue [d(CH2)5(1),Tyr(Me)2]AVP facilitated retrieval of passive avoidance in all animals.
摘要
我们研究了单次2微克剂量的血管加压素（AVP）类似物[(CH2)5(1),Tyr(Me)2]AVP对实验性诱导失忆大鼠条件反射恢复过程的影响。所使用的模型为：电惊厥休克（ECS）和缺氧。这两种模型严重损害了记忆过程。AVP类似物[d(CH2)5(1),Tyr(Me)2]AVP促进了所有动物被动回避反应的恢复。
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