Kellner H, Yu D
Medizinische Poliklinik, Klinikum Innenstadt, Universität München, Germany.
Clin Investig. 1994 Mar;72(4):321-8. doi: 10.1007/BF00180051.
The most remarkable association between a major histocompatibility complex antigen and disease susceptibility--HLA-B27 and seronegative spondyloarthropathies, particularly ankylosing spondylitis--was discovered 20 years ago. During the two intervening decades advances in basic immunology and molecular biology have not only revealed the biosynthesis and structure of HLA-B27 but also given clues to the basic function of this molecule, the presentation of allele-specific peptides to CD8+ cytotoxic T cells. The recently reported three-dimensional structure of HLA-B27 and the identification of self-peptides bound to this major histocompatibility complex class I antigen can be viewed as a landmark in the understanding of the pathogenic role of HLA-B27. Based on crystallographic evidence, a peptide-binding motif can be postulated that should allow identification of HLA-B27 complexed peptides which may trigger an immune reaction causing arthritis.
20年前发现了主要组织相容性复合体抗原与疾病易感性之间最显著的关联——HLA - B27与血清阴性脊柱关节病，尤其是强直性脊柱炎。在这期间的二十年里，基础免疫学和分子生物学的进展不仅揭示了HLA - B27的生物合成和结构，还为该分子的基本功能——向CD8 + 细胞毒性T细胞呈递等位基因特异性肽提供了线索。最近报道的HLA - B27三维结构以及与这种主要组织相容性复合体I类抗原结合的自身肽的鉴定，可被视为理解HLA - B27致病作用的一个里程碑。基于晶体学证据，可以推测出一种肽结合基序，该基序应能识别可能引发导致关节炎的免疫反应的与HLA - B27复合的肽。
