Monaco J J, Cho S, Attaya M
Department of Microbiology and Immunology, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0678.
Science. 1990 Dec 21;250(4988):1723-6. doi: 10.1126/science.2270487.
T lymphocyte activation requires recognition by the T cell of peptide fragments of foreign antigen bound to a self major histocompatibility complex (MHC) molecule. Genetic evidence suggests that part of the class II region of the MHC influences the expression, in trans, of MHC class I antigens on the cell surface, by regulating the availability of peptides that bind to and stabilize the class I molecule. Two closely related genes in this region, HAM1 and HAM2, were cloned and had sequence similarities to a superfamily of genes involved in the ATP-dependent transport of a variety of substrates across cell membranes. Thus, these MHC-linked transport protein genes may be involved in transporting antigen, or peptide fragments thereof, from the cytoplasm into a membrane-bounded compartment containing newly synthesized MHC molecules.
T淋巴细胞激活需要T细胞识别与自身主要组织相容性复合体（MHC）分子结合的外来抗原肽片段。遗传学证据表明，MHC II类区域的一部分通过调节与I类分子结合并使其稳定的肽的可用性，反式影响MHC I类抗原在细胞表面的表达。该区域的两个密切相关基因HAM1和HAM2被克隆出来，它们与一个参与多种底物跨细胞膜的ATP依赖性转运的基因超家族具有序列相似性。因此，这些与MHC连锁的转运蛋白基因可能参与将抗原或其肽片段从细胞质转运到含有新合成的MHC分子的膜结合区室中。
