Guze B H, Gitlin M
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
J Neuropsychiatry Clin Neurosci. 1994 Spring;6(2):114-21. doi: 10.1176/jnp.6.2.114.
Attempts to elucidate the pathophysiology of symptom production in mood disorders can be enhanced by information from two sources. First, insights into localization can be gained from the secondary mood disorders; these clinical problems suggest the brain regions that, when altered, are associated with specific symptoms. Second, both structural and functional brain imaging suggest specific regions where abnormalities are associated with mood disorders. Data that emerge from these sources implicate the basal ganglia, frontal cortex, and temporal lobes in the production of mood disorder symptoms. However, the specific neuroanatomic subregions involved and the associated biochemical changes await full elucidation.
来自两个方面的信息可以增进我们对情绪障碍症状产生的病理生理学的理解。首先，继发性情绪障碍能让我们了解症状的定位；这些临床问题提示了大脑中发生改变时与特定症状相关的区域。其次，大脑结构和功能成像显示了与情绪障碍相关的特定异常区域。这些来源的数据表明基底神经节、额叶皮质和颞叶与情绪障碍症状的产生有关。然而，具体涉及的神经解剖亚区域以及相关的生化变化仍有待充分阐明。
