Hori H, Kasai T, Haratake J, Ishimatsu S, Oyabu T, Yamato H, Higashi T, Tanaka I
Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, Kitakyushu, Japan.
Occup Environ Med. 1994 Jul;51(7):492-9. doi: 10.1136/oem.51.7.492.
Male Wistar rats were exposed to two types of magnesium sulphate whiskers by inhalation for six hours a day, five days a week, for four weeks (sub-chronic study), or for one year (chronic study) to clarify the biological effects of the whiskers. There were few whiskers detected in the rat lungs even at one day after the exposure, suggesting that they are dissolved and eliminated rapidly from the lungs. To measure the clearance rate of the whiskers from the lungs, an intratracheal instillation was performed in golden hamsters. The half life of the whiskers in the lung was determined as 17.6 minutes by temporally measuring the magnesium concentration up to 80 minutes after the instillation. A histopathological examination indicated a frequent occurrence of adenoma and carcinoma in the year after chronic exposure, but it was not significantly different between exposed and control rats.
雄性Wistar大鼠每周5天、每天6小时吸入两种硫酸镁晶须，持续4周（亚慢性研究）或1年（慢性研究），以阐明晶须的生物学效应。即使在暴露后一天，在大鼠肺部也几乎检测不到晶须，这表明它们会迅速从肺部溶解并清除。为了测量晶须从肺部的清除率，对金黄仓鼠进行了气管内滴注。通过在滴注后长达80分钟的时间内测量镁浓度，确定晶须在肺部的半衰期为17.6分钟。组织病理学检查表明，慢性暴露后一年内腺瘤和癌的发生率较高，但暴露组和对照组大鼠之间无显著差异。
