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半乳糖脑苷脂抗体在实验性变态反应性脑脊髓炎中的作用

Role of antibodies to galactocerebroside in experimental allergic encephalomyelitis.

作者信息

Hughes R A, Leibowitz S

出版信息

Immunology. 1975 Feb;28(2):213-8.

PMID:804435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445798/
Abstract

The possible role of antibodies to galactocerebroside was investigated in AS rats with experimental allergic encephalomyelitis (EAE) induced by guinea-pig spinal cord. Passive immunization with rat or rabbit antiserum to galactocerebroside did not protect rats from EAE. Active immunization with galactocerebroside before the encephalitogenic challenge produced antibody to galactocerebroside but also failed to protect rats from EAE. These experiments did not support previous suggestions that antibodies to galactocerebroside are protective.

摘要

在由豚鼠脊髓诱导产生实验性变应性脑脊髓炎（EAE）的AS大鼠中，研究了抗半乳糖脑苷脂抗体的可能作用。用大鼠或兔抗半乳糖脑苷脂抗血清进行被动免疫并不能保护大鼠免受EAE侵害。在致脑炎攻击前用半乳糖脑苷脂进行主动免疫产生了抗半乳糖脑苷脂抗体，但同样未能保护大鼠免受EAE侵害。这些实验不支持先前关于抗半乳糖脑苷脂抗体具有保护作用的观点。

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The effect of prior injections of tissue antiserums on the survival of cancer homoiografts in mice.预先注射组织抗血清对小鼠体内癌同种移植物存活的影响。
Cancer Res. 1952 Feb;12(2):110-2.
2
Suppression of allergic encephalomyelitis in rats by means of antibrain serum.通过抗脑血清抑制大鼠过敏性脑脊髓炎。
J Exp Med. 1963 May 1;117(5):755-74. doi: 10.1084/jem.117.5.755.
3
Specificity of encephalitogen-induced inhibition of experimental "allergic" encephalomyelitis in the guinea pig.脑脊髓炎原诱导的豚鼠实验性“过敏性”脑脊髓炎抑制作用的特异性
J Immunol. 1962 Jul;89:54-61.
4
Dissociation of antibody production from disease suppression in the inhibition of allergic encephalomyelitis by myelin basic protein.髓鞘碱性蛋白抑制过敏性脑脊髓炎过程中抗体产生与疾病抑制的解离
J Immunol. 1970 Jun;104(6):1435-46.
5
The susceptibility of rat strains to experimental allergic encephalomyelitis.大鼠品系对实验性变应性脑脊髓炎的易感性。
Immunology. 1973 May;24(5):879-84.
6
Protection of rats from experimental allergic encephalomyelitis with antiserum to guinea-pig spinal cord.用豚鼠脊髓抗血清保护大鼠免受实验性变应性脑脊髓炎侵害。
Immunology. 1974 Apr;26(4):703-11.
7
Immunologic unresponsiveness, immunity and enhancement in experimental allergic encephalomyelitis.实验性变应性脑脊髓炎中的免疫无反应性、免疫性及增强作用。
J Immunol. 1968 Jul;101(1):33-42.
8
Immunopathologic response in guinea pigs sensitized with peripheral nervous system myelin.
Brain Res. 1973 Aug 30;58(2):500-5. doi: 10.1016/0006-8993(73)90021-8.

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