支原体的适应性表面变异
Adaptive surface variation in mycoplasmas.
作者信息
Wise K S
机构信息
Dept of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia 65212.
出版信息
Trends Microbiol. 1993 May;1(2):59-63. doi: 10.1016/0966-842x(93)90034-o.
Abstract
Mycoplasmas excel as infectious agents, despite their very small genomes. In one mycoplasma species, adaptive flexibility is enhanced by an elegant genetic system that diversifies the membrane surface through a set of variable lipoproteins (Vlps). A family of vlp genes supplies divergent coding sequences and undergoes high-frequency mutations, thus creating large repertoires of surface mosaics and structural variants.
摘要
支原体尽管基因组非常小，但作为感染因子却表现出色。在一种支原体物种中，一种精妙的遗传系统增强了其适应性灵活性，该系统通过一组可变脂蛋白（Vlps）使膜表面多样化。一个vlp基因家族提供不同的编码序列并经历高频突变，从而产生大量的表面镶嵌体和结构变体。
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The Vlp system of Mycoplasma hyorhinis: combinatorial expression of distinct size variant lipoproteins generating high-frequency surface antigenic variation.猪鼻支原体的Vlp系统：不同大小变异脂蛋白的组合表达产生高频表面抗原变异。
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EMBO J. 1991 Dec;10(13):4069-79. doi: 10.1002/j.1460-2075.1991.tb04983.x.
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