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细胞介导的抗菌免疫表达中骨髓来源成分的需求。

Requirement for a bone marrow-derived component in the expression of cell-mediated antibacterial immunity.

作者信息

Hahn H

出版信息

Infect Immun. 1975 May;11(5):949-54. doi: 10.1128/iai.11.5.949-954.1975.

DOI:10.1128/iai.11.5.949-954.1975
PMID:804449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC415163/
Abstract

Mice were X irradiated with 400 R and 1 week post-irradiation were found to be unable to develop antilisterial immunity after active or passive immunization with immunologically committed spleen lymphocytes from Listeria-immune donors. This consequence of irradiation disappeared spontaneously within 21 days of exposure to X rays. Mice irradiated with as much as 900 R could be passively protected by immunologically committed lymphoid cells from Listeria-immune donors 10 days after irradiation if they had been given normal bone marrow cells on the day or irradiation. It is concluded that, in addition to immunologically committed lymphocytes, a second cellular component is needed for the expression of antibacterial immunity. This second component is bone marrow derived.

摘要

小鼠接受400伦琴的X射线照射，照射后1周发现，用来自对李斯特菌免疫的供体的免疫活性脾淋巴细胞进行主动或被动免疫后，它们无法产生抗李斯特菌免疫力。这种辐射的后果在暴露于X射线后21天内自发消失。如果在照射当天给予正常骨髓细胞，接受高达900伦琴照射的小鼠在照射后10天可以被来自对李斯特菌免疫的供体的免疫活性淋巴细胞被动保护。得出的结论是，除了免疫活性淋巴细胞外，表达抗菌免疫力还需要第二种细胞成分。这种第二种成分来源于骨髓。

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