Mulcahy H E, Patchett S E, Daly L, O'Donoghue D P
Gastroenterology and Liver Unit, St Vincent's Hospital, Dublin, Ireland.
Br J Surg. 1994 May;81(5):736-8. doi: 10.1002/bjs.1800810540.
The effect of age on the presentation, diagnosis, management and survival of patients with colorectal cancer was studied prospectively in 512 patients admitted to a single institution. In all, 225 patients were aged 70 years or more and 287 less than 70 years. Older patients had a significant excess of emergency presentations (18 versus 11 per cent). Methods of diagnosis, proportion of curative operations performed, stage and histological grade were similar in the two age groups. The postoperative mortality rate was 6 per cent in the elderly group and 3 per cent in younger patients. The postoperative mortality rate rose to 15 and 12 per cent respectively in those undergoing emergency surgery. The relative 5-year survival rate standardized for age and sex was 52 per cent for older patients and 45 per cent for younger patients; for those undergoing curative surgery it was 68 and 59 per cent respectively. The behaviour of colorectal carcinoma changes little with age and, allowing for population mortality, age has no effect on the long-term survival of elderly patients with large bowel cancer.
对一家机构收治的512例结直肠癌患者进行了前瞻性研究，以探讨年龄对结直肠癌患者的临床表现、诊断、治疗及生存情况的影响。其中，225例患者年龄在70岁及以上，287例患者年龄小于70岁。老年患者急诊就诊比例显著更高（分别为18%和11%）。两个年龄组的诊断方法、根治性手术比例、分期及组织学分级相似。老年组术后死亡率为6%，年轻患者为3%。急诊手术患者的术后死亡率分别升至15%和12%。经年龄和性别标准化后的相对5年生存率，老年患者为52%，年轻患者为45%；接受根治性手术的患者分别为68%和59%。结直肠癌的生物学行为随年龄变化不大，考虑到总体死亡率，年龄对老年结直肠癌患者的长期生存无影响。
