Cutrona C E, Cadoret R J, Suhr J A, Richards C C, Troughton E, Schutte K, Woodworth G
Department of Psychology, University of Iowa, Iowa City.
Compr Psychiatry. 1994 May-Jun;35(3):171-9. doi: 10.1016/0010-440x(94)90188-0.
The contributions of genetic and both positive and negative environmental factors were tested in the prediction of alcohol abuse/dependence among 300 adult adoptees. No direct effects for either genetic or environmental factors were significant in the prediction of adoptee alcohol abuse/dependence. However, among women, early-life family conflict and psychopathology in the adoptive family interacted with a biological background of alcoholism. Among women with at least one alcoholic biological parent, conflict or psychopathology in the adoptive family increased the probability of alcohol abuse and/or dependence. Among men, no significant interactions were found between a biological background of alcoholism and environmental variables. Results suggest a pattern of gene-environment interaction among women.
在对300名成年领养者的酒精滥用/依赖预测中，对遗传因素以及积极和消极环境因素的作用进行了测试。在领养者酒精滥用/依赖的预测中，遗传因素或环境因素的直接作用均不显著。然而，在女性中，领养家庭早年的家庭冲突和精神病理学与酗酒的生物学背景相互作用。在至少有一位酗酒亲生父母的女性中，领养家庭中的冲突或精神病理学增加了酒精滥用和/或依赖的可能性。在男性中，未发现酗酒生物学背景与环境变量之间存在显著的相互作用。结果表明女性中存在基因-环境相互作用模式。
