Wang Z X, Chai B F, Ye Y Q
Ruijin Hospital, Shanghai Second Medical University.
Zhonghua Wai Ke Za Zhi. 1994 Jan;32(1):61-3.
Thirty rabbits were divided equally into 5 groups randomly. A hole, 6mm in diameter and 2mm deep, was bored on both ilia of the thirty animals. Two cubes of alumina were implanted into the hole on one side of each animal, while the hole on the opposite side served as control. Six rabbits each were sacrificed on 10, 20, 40, 60 and 90 days after operation. Calcium, phosphorus and aluminium contents of bone tissues in and around both holes were determined by Inductively Coupled Plasma-Atomic Emission Spectrometry. The results show that the aluminium content of the bone tissues on the implanted side in each group was higher than that of the control with statistically significant difference in the 10-, 40- and 60-day groups (P < 0.05). This means that the implantation definitely releases aluminium into the bone tissues. On the contrary, calcium and phosphorus contents were significantly lower in the bone tissues on the implanted side than in the control side in the 10- and 20-day groups (P < 0.05-0.001). It implies that the aluminium released from the implant in the early stage can interfere with the metabolism of calcium and phosphorus and thus delay the mineralization of the bone tissues.
30只兔子被随机均分为5组。在这30只动物的双侧髂骨上钻一个直径6mm、深2mm的孔。在每只动物一侧的孔中植入两块氧化铝立方体，而另一侧的孔作为对照。术后10、20、40、60和90天分别处死6只兔子。采用电感耦合等离子体原子发射光谱法测定双侧孔及其周围骨组织中的钙、磷和铝含量。结果显示，每组植入侧骨组织中的铝含量均高于对照侧，在10天、40天和60天组差异有统计学意义（P<0.05）。这表明植入确实会向骨组织中释放铝。相反，在10天和20天组中，植入侧骨组织中的钙和磷含量明显低于对照侧（P<0.05 - 0.001）。这意味着早期从植入物中释放的铝会干扰钙和磷的代谢，从而延迟骨组织的矿化。
