抗寄生虫硝基咪唑。8. 2-(4-甲酰基苯乙烯基)-5-硝基-1-乙烯基咪唑的衍生物。
Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole.
作者信息
Ross W J, Jamieson W B
出版信息
J Med Chem. 1975 Feb;18(2):158-61. doi: 10.1021/jm00236a009.
PMID:804551
Abstract
A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard reagent P), and dimethylaminoacetohydrazide (Girard reagent D) displayed good activity against Trypanosoma rhodesiense.
摘要
制备了一系列2-(4-甲酰基苯乙烯基)-5-硝基-1-乙烯基咪唑的33种硫缩醛和腙，并对其抗锥虫特性进行了研究。硫缩醛作为抗锥虫剂没有活性，但三种衍生自N-氨基胍、氯化吡啶基乙酰肼（吉拉德试剂P）和二甲基氨基乙酰肼（吉拉德试剂D）的腙对罗德西亚锥虫显示出良好的活性。
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