Valverde D, Bayés M, Martínez I, Grinberg D, Vilageliu L, Balcells S, Gonzàlez-Duarte R, Baiget M
Unitat de Genètica Molecular, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Hum Genet. 1994 Aug;94(2):193-4. doi: 10.1007/BF00202869.
Arrestin is a component of the light transduction cascade that takes place in the outer segment of retinal rods. In situ hybridization and linkage analysis have localized the arrestin gene to a region of 50 cM between CRYG alpha and D2S23/D2S55 on chromosome 2q24-37. We have performed pairwise and multipoint linkage analysis between arrestin and four highly polymorphic markers from this region. The results indicate tight linkage between the gene and the microsatellite D2S172 (Zmax = 9.25 at theta = 0.038). This fine localization of the gene should provide a useful tool for cosegregation analyses involving the arrestin gene.
抑制蛋白是视网膜视杆细胞外段发生的光转导级联反应的一个组成部分。原位杂交和连锁分析已将抑制蛋白基因定位到2号染色体q24 - 37上CRYGα与D2S23/D2S55之间50厘摩的区域。我们对该区域的抑制蛋白与四个高度多态性标记进行了成对和多点连锁分析。结果表明该基因与微卫星D2S172紧密连锁（在θ = 0.038时Zmax = 9.25）。该基因的这种精细定位应为涉及抑制蛋白基因的共分离分析提供一个有用的工具。
