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血管紧张素转换酶基因的缺失多态性与空腹血糖水平升高有关。

Deletion polymorphism in the gene for angiotensin converting enzyme is associated with elevated fasting blood glucose levels.

作者信息

Zingone A, Dominijanni A, Mele E, Marasco O, Melina F, Minchella P, Quaresima B, Tiano M T, Gnasso A, Pujia A

机构信息

Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Reggio Calabria, Catanzaro, Italy.

出版信息

Hum Genet. 1994 Aug;94(2):207-9. doi: 10.1007/BF00202873.

DOI:10.1007/BF00202873
PMID:8045571
Abstract

The frequency and distribution of angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism, and its association with other known risk factors for coronary atherosclerosis, has been studied, in a normal south Italian population. Subjects homozygous for deletion showed elevated fasting blood glucose levels when compared with subjects homozygous for insertion. The difference was consistent with an increased number of type 2 diabetics among the former group of subjects.

摘要

在意大利南部的正常人群中，研究了血管紧张素转换酶插入/缺失（ACE I/D）多态性的频率和分布，以及它与冠状动脉粥样硬化其他已知危险因素的关联。与插入纯合子受试者相比，缺失纯合子受试者的空腹血糖水平升高。这种差异与前一组受试者中2型糖尿病患者数量的增加一致。

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