Volovitz B, Shohat B, Amir J, Nussinovitch M, Varsano I
Department of Pediatrics, Children's Medical Centre of Israel, Petah Tikva.
Isr J Med Sci. 1994 Aug;30(8):572-7.
Corticosteroids are known to affect the number and function of circulating lymphocytes in humans. The effect of 2 years administration of inhaled budesonide (200 micrograms/day) on the number and function of B and T lymphocytes and T cell subsets was evaluated in 16 young children with severe asthma. The number of T and B cells and T suppressor/cytotoxic cells (CD8 T cell) and T helper/inducer cells (CD4 T cell) before therapy was found to be comparable to the number of cells observed in the healthy control group. Two years administration of inhaled budesonide did not significantly alter the percentage and absolute number of all these cells. The functional activity of T lymphocytes was evaluated by the "local xenogeneic graft versus host reaction" (GVHR). A positive (normal) GVHR was observed in only 5 of the 16 children (31%) in the budesonide group before therapy, compared to 15 of 16 children (94%) in the healthy control group. During the 2 years treatment with inhaled budesonide, the percentage of patients having positive GVHR increased from 31% before therapy to 69% and 77% after 1 and 2 years of therapy (P = 0.05 and 0.02), respectively. The data observed in this study indicate that 2 years administration of inhaled budesonide did not alter the number of B and T lymphocytes and T cell subsets. However, it was associated with improvement in the GVHR function of T cells.
已知皮质类固醇会影响人体循环淋巴细胞的数量和功能。在16名重度哮喘幼儿中评估了吸入布地奈德（200微克/天）两年对B淋巴细胞、T淋巴细胞及T细胞亚群数量和功能的影响。发现治疗前T细胞、B细胞、T抑制/细胞毒性细胞（CD8 T细胞）和T辅助/诱导细胞（CD4 T细胞）的数量与健康对照组中观察到的细胞数量相当。吸入布地奈德两年并未显著改变所有这些细胞的百分比和绝对数量。通过“局部异种移植物抗宿主反应”（GVHR）评估T淋巴细胞的功能活性。治疗前，布地奈德组16名儿童中只有5名（31%）观察到阳性（正常）GVHR，而健康对照组16名儿童中有15名（94%）观察到阳性GVHR。在吸入布地奈德治疗的两年期间，具有阳性GVHR的患者百分比从治疗前的31%分别增加到治疗1年和2年后的69%和77%（P = 0.05和0.02）。本研究中观察到的数据表明，吸入布地奈德两年并未改变B淋巴细胞、T淋巴细胞及T细胞亚群的数量。然而，它与T细胞GVHR功能的改善有关。
