Gempp-Friedrich W, Prellwitz W
Klin Wochenschr. 1975 Jan;53(1):44-6. doi: 10.1007/BF01466857.
Analysis of human serum aldolase isoenzymes A, B and C activities was performed by means of a recently developed immunochemical assay. Isoenzyme patterns were established in 130 healthy subjects selected from a normal range research program. Total aldolase activity ranged from 0.8, 1.6, 2.5 U/L, Ald A from 0.6, 1.2, 1.9 U/L, Ald B 0.0, 0.2, 0.7 U/L, Ald C 0.0, 0.1, 0.4 U/L expressed as chi plus or minus 2 s range. Comparing the histograms of total aldolase activity in patients with acute hepatitis and normal controls, an almost identical frequency distribution in both groups was observed. However, histograms of aldolase isoenzyme B values of these groups were practically completely separated. Thus in contrast with total aldolase activity, the determination of aldolase isoenzyme B activity is a useful criterion in the diagnosis of acute hepatitis.
采用最近开发的免疫化学分析法对人血清醛缩酶同工酶A、B和C的活性进行了分析。从正常范围研究项目中选取了130名健康受试者，建立了同工酶模式。总醛缩酶活性范围为0.8、1.6、2.5 U/L，醛缩酶A为0.6、1.2、1.9 U/L，醛缩酶B为0.0、0.2、0.7 U/L，醛缩酶C为0.0、0.1、0.4 U/L，以χ±2s范围表示。比较急性肝炎患者和正常对照者总醛缩酶活性的直方图，两组的频率分布几乎相同。然而，这些组的醛缩酶同工酶B值的直方图实际上完全分开。因此，与总醛缩酶活性相反，醛缩酶同工酶B活性的测定是诊断急性肝炎的一个有用标准。
