Kallistratos G
MMW Munch Med Wochenschr. 1975 Mar 7;117(10):391-4.
The carcinogenic action of 3,4-benzpyrene (3,4-BP) can be reduced or completely inhibited by the presence of substances which occur in the animal organism and also by compounds prepared synthetically. Experiments in female mice have shown that the addition of some unsaturated aliphatic dicarboxylic and tricarboxylic acids, thiols or biogenic amines to 3,4-benzyprene solutions causes a slowing down of the tumor induction or complete blockade of the tumor development. The same 3,4-BP solutions without the addition of the substances mentioned produced malignant tumors in the mice almost without exception.
动物机体中存在的物质以及合成制备的化合物能够降低或完全抑制3,4-苯并芘（3,4-BP）的致癌作用。对雌性小鼠的实验表明，向3,4-苯并芘溶液中添加某些不饱和脂肪族二羧酸和三羧酸、硫醇或生物胺会导致肿瘤诱发减缓或肿瘤发展完全受阻。未添加上述物质的相同3,4-BP溶液几乎无一例外地在小鼠体内引发了恶性肿瘤。
